KCC2, the neuronal chloride extruder that keeps GABA-A signaling inhibitory,…
BRAIN SLICE ELECTROPHYSIOLOGY, CELL ELECTROPHYSIOLOGY,…
What makes a human CNS assay predictive for target engagement? …
CRO, EX-VIVO STUDIES, HUMAN RELEVANT…
Why human-relevant assays matter when rodent data are not enough …
BRAIN SLICE ELECTROPHYSIOLOGY, EX-VIVO STUDIES,…
Why assay choice matters in human-relevant CNS drug discovery Rodent…
BRAIN SLICE ELECTROPHYSIOLOGY, CRO, EX-VIVO…
Choosing the right human-relevant CNS assay for target engagement For…
CRO, HUMAN RELEVANT ASSAYS, NAM
Some anti-epileptic and analgesic drugs work by blocking the channels…
CELL ELECTROPHYSIOLOGY, CRO, IPSC CELLS
Human-induced pluripotent stem cell (iPSC)-derived neurons offer a uniquely relevant…
CELL ELECTROPHYSIOLOGY, IN VITRO ELECTROPHYSIOLOGY,…
Epilepsy is fundamentally a disorder of runaway electrical activity —…
CELL ELECTROPHYSIOLOGY, CORTICAL NEURONS, CRO,…
In preclinical CNS and pain drug discovery, platform choice is governed by biology resolution rather than…
CRO, MULTIELECTRODE ARRAY, PAIN, PATCH…
