Cell Electrophysiology

Based in San Diego, California, our in vitro cell electrophysiology platform benefits from 17 years of experience of Neuroservices-Alliance in providing pharmacological assays based on electrophysiological recordings, and focuses on cells recordings (human iPSC-derived neurons, DRG sensory neurons from rodent, cyno, non human primate).

Thanks to efficient and collaborative scientific interactions and robust functional data, our cell electrophysiology work supports decision making in any phases of CNS or PAIN drug discovery research programs.

Expertise in CNS & PNS cell electrophysiology

Thanks to a complete master of the Patch Clamp and Calcium Imaging techniques, our cell electrophysiology experts investigate your compound’s effects on neuronal networks and single neurons:

Clonned channels and receptors
Brain neuron cultures (rodents)
DRG sensory neurons cultures (cyno, nhp, rabbit)
iPSC- derived neurons from human donors (healthy or patients)

Depending on the pathology targeted by your compound, our researchers propose protocols tailored to your needs to reveal your compound properties: pharmacological properties, target(s), Mechanism(s) of Action and Safety issues.

Our cell electrophysiology platform also proposes electrophysiological characterization services of iPSC-derived neurons (proprietary or commercial cell lines).

Our techniques & models

Patch Clamp

Neuroservices-Alliance is a world-renowned leader in patch clamp electrophysiology. Patch Clamp allows in vitro evaluation of compounds under the most physiologically relevant conditions.

Calcium imaging

Calcium Imaging is a mid-throughput technique used to evaluate Calcium ions activity in functioning neurons.

By measuring individual cells or global neuronal networks calcium dynamics, Calcium Imaging allows a high resolution analysis of studied neuronal culture.

Our analysis tool allow focus on area of interest, so that AP firing can be measured locally.

View of lfuorscent neurons thanks to calcium imaging

High Density Multi Electrode Array

Thanks to our partnership with Maxwell Biosystems, our cell electrophysiology laboratory is equipped with a MaxTwo 6-wells High Density MEA recording system. Our team can perform recordings and analysis of neuron populations of single cell at a sub-cellular resolution.

Thanks to High Density MEA, we help understand the global firing activity of your neuronal culture and determine the validity of your culture.