In vivo Spinal Cord Electrophysiology

Spinal cord recording can be used to validate new pain therapeutic targets and/or assess drug efficacy in recognized pain models thanks to robust electrophysiological data. It represents an essential technique to evaluate the analgesic potential of drug candidates. Recordings are performed extracellularly in deeply anesthetized rodents under control physiological conditions.

More about E-Phys capabilities

Webinar – in vivo recordings of spinal and DRG neurons

The release of novel non-opioid analgesic drugs requires innovative R&D strategies. In this line, the measure of the activity of nociceptors in the dorsal root ganglia and neurons involved in the generation of pain sensation in the spinal cord provides a unique way of assessing the analgesic efficacy of drug candidates on pain-specific endpoints. The aim of this presentation is to give a brief overview on the use of these methods in anesthetized mice and rats to assist pain drug discovery.

Pharmacology & Therapeutic areas

Supporting clients working in therapeutic areas such as:

• Pain

Example target classes we cover

• Ligand-gated ion channels
• Voltage-gated ion channels
• G-protein coupled receptors (GPCRs)

Example drug targets we cover

• TRPV1
• Nav1.7
• MOR

Techniques & Models