E-Phys’ has many years of experience in the drug discovery field and collaborates with experts from the CROs and large pharmaceutical companies.
Spinal cord recording can be used to validate new pain therapeutic targets and/or assess drug efficacy in recognized pain models thanks to robust electrophysiological data. It represents an essential technique to evaluate the analgesic potential of drug candidates. Recordings are performed extracellularly in deeply anesthetized rodents under control physiological conditions.
The release of novel non-opioid analgesic drugs requires innovative R&D strategies. In this line, the measure of the activity of nociceptors in the dorsal root ganglia and neurons involved in the generation of pain sensation in the spinal cord provides a unique way of assessing the analgesic efficacy of drug candidates on pain-specific endpoints. The aim of this presentation is to give a brief overview on the use of these methods in anesthetized mice and rats to assist pain drug discovery.
Supporting clients working in therapeutic areas such as:
Example target classes we cover
Example drug targets we cover
"Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids"
. 2023 Jun 15;S0896-6273(23)00397-5. doi: 10.1016/j.neuron.2023.05.024.
"Physiological properties of the lamina I spinoparabrachial neurons in the mouse"
. 2019 Apr;597(7):2097-2113. doi: 10.1113/JP277447.
Novel non-opioid analgesics necessitate innovative R&D strategies, including assessing the efficacy of drug candidates on pain-specific endpoints. Measuring nociceptor activity in the dorsal root ganglia and pain-sensing neurons in the spinal cord offers a unique approach. This presentation provides a concise overview of using these methods in anesthetized mice and rats for pain drug discovery.Learn more
"Differential sensitization of lamina I and lamina III-V neurons projecting to and/or through the parabrachial area in chronic inflammatory condition in anaesthetized mice."Learn more