Brain Slice Electrophysiology

Scientists working

Based in Aix-en-Provence, France, our Brain Slice Electrophysiology platform is the global leader in in vitro slice electrophysiological assays for CNS and PNS pharmacology. 

With over 17 years of experience, we specialize in Patch Clamp and Multi Electrode Array (MEA) and High-Density MEA recordings from acute brain and spinal cord slices. 

Our expertise lies in designing, executing, and analyzing and interpreting complex electrophysiological/pharmacological protocols, providing functional data allowing decision making for CNS or Pain Drug Discovery programs. 

Electrophysiological recordings of acute brain slices, spinal cord slices, and cultured neurons.

We can address any type of spinal of receptor and brain region, spinal cord and electrophysiological protocol on any type of rodent (wild type or TG) 

 

Worfklow neuroservices alliance diagram

 

 

Our techniques & models

Patch Clamp

Neuroservices-Alliance is a world-renowned leader in patch clamp electrophysiology. Patch Clamp allows in vitro evaluation of compounds with the highest cell/molecular resolution. 

Neuroservice Expertise patch clamp

Multi Electrode Array (MEA)

Multi Electrode Array (MEA) is a mid-throughput technique enabling parallel and multi-sites extra-cellular recordings within a single brain slice. Multi Electrode Array is the adequate technique to get an exceptional macroscopic view of neuronal networks.

Click here to learn more

Multi Electrode Array brain slice

HD-MEA

HD-MEA allows recording of neuronal networks almost at the cellular levels. Proprietary AI algorithms allow extracting thousands or millions of information with an unprecedented resolution.

More information

macroscopic view of neurons on MEA plate

Disease Models

  • Pain (acute /chronic) 
    Dedicated assays for pain-killer compounds: spinal cord recordings and discrimination between layers 1-2 and layers 4-5 in the dorsal horn. Based on the MEA technique, we also provide a quick screening assay on capsaicin-evoked firing activity (validated with reference compounds). 
  • Epilepsy / Ischemic / OGD (Oxygen-Glucose Deprivation) 
  • Stress/Anxiety 
Multi Electrode Array brain slice

Tg Models

We have a long experience in characterizing genetically-modified rodents (mice or rats) for many neurodegenerative, epileptic  and neuro-muscular diseases. 

Compounds can be evaluated in brain slices or spinal cord slices prepared from commercially available transgenic mice or rats (acute exposure or chronic exposure). 

Recordings can be performed in slices prepared from rats (up to 18 months) or mice (up to 24 months). 

SLICE ELECTROPHYSIOLOGY OFFER

Download our one-pager for a comprehensive overview of our brain slice in vitro electrophysiology solutions for CNS and Pain preclinical drug discovery.

Learn more

CASE STUDY - EPILEPSY

In vitro model for pro- or anti- epileptic drug profiling

Learn more

CASE STUDY - PAIN

Profiling of painkiller drugs

Learn more

CASE STUDY - NEURODEGENERATIVE DISEASES

Tg rodent phenotyping

Learn more

CASE STUDY - PATCH CLAMP RECORDING OF STRIATAL SLICES - mEPSCs

We have strong experience in characterizing electrophysiological properties of MSNs in HD mouse models (including R6/2 and zQ175) with or without chronic dosing treatments or acute compound exposure.

Learn more

DATA SHEET - WE SUPPORT RESEARCH PROGRAMS TARGETING CATION-CHLORIDE COTRANSPORTERS

Using the perforated patch-clamp technique, we can provide experimental scientific support to drug discovery programs targeting cation-chloride cotransporters.

Learn more

CASE STUDY - CATION-CHLORIDE COTRANSPORTERS

Using the perforated patch-clamp technique, we can provide experimental scientific support to drug discovery programs targeting cation-chloride cotransporters.

Learn more

A7nachR HBS

Learn more

Brain Slice Electrophysiology Experts

Alexander Barre, Phd
Patch Clamp Engineer
Camille Bonnin
Patch Clamp Engineer
Camille Sanson
Patch Clamp Engineer
Fabrice Robert
Head of Animal Facilities
Hélène Savinel
MEA Engineer
Julien Artinian, PhD
Head of Slice Electrophysiology Lab
Bruno Buisson, PhD
Co-Founder, President & CSO
Romain Teyssie
MEA Engineer
Saber Graf
Corporate IT & AI Strategy Manager
Sungjae Yoo, PhD
Patch Clamp Engineer
Vanessa Veyrier
Patch Clamp Engineer