Anxiety / Stress / PTSD

Several types of anxiety

Anxiety is a common mechanism that can turn into a chronic disease when it occurs at times it is not supposed to. Anxiety can take several forms: generalized anxiety, phobia, panic attacks, Obsessional Compulsive Disorder (OCD) or Post-Traumatic Stress Disorder (PTSD).

Generalized anxiety is the most common anxiety among the population. About 5 to 8% of worldwide population suffers from generalized anxiety and women are particularly more affected (about 10% of women over 40 years old).

Post Traumatic Stress Disorder occurs after exposure to a traumatic event (war, terrorist attacks, fights, rapes…). Individuals affected by PTSD display intense and disproportionate fearful reactions, helplessness feeling and other symptoms that can last many years after the traumatic event that triggered PTSD.

Anxiety, Stress & PTSD Models

in vitro models

• Our brain slice electrophysiology platform proposes electrophysiological assays on stress models

in vivo behavioural models

• Our in vivo brain electrophysiology platform for rodent models of neurological disorders has developed a behavioural model based on the clinical dimensions of PTSD. This model is coupled with electrophysiology and optogenetics approaches in behaving animals. It is is particularly suited for evaluating the impact of specific pharmacological compounds on neuronal activity.
• Key-Obs, our preferred partner expert in behavioural models of neurological disorders, offers several tests to assess compound efficacy:
  • Four-plate test
  • Stress induced in elevated plus maze
  • Stress-induced hyperthermia

Are you currently working on compounds targeting anxiety, stress or PTSD?

Please contact us for any additional information and we will gladly come back to you. We can also set up a dedicated meeting between you and our experts to discuss our CRO services and your research needs.