Epilepsy: a chronic disorder
Epilepsy is one of the most common neurological conditions, and affects more than 50 millions people throughout the world. Epilepsy describes recurrent and unprovoked (not related to another immediate specific health condition) seizures suffered by an individual. Epilepsy is most commonly diagnosed in children and adolescents, or later on in life when cardiovascular diseases and stroke risk increases.
Even though family factor and brain injury can be the source of unprovoked seizures, in most cases the original cause is unknown.
in vitro and in vivo models of Epilepsy
in vitro models
- Our brain slice electrophysiology platform proposes in vitro assays to help your Anti-Epileptic Drug (AED) research programs.
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- In vitro model for pro-or anti-epileptic drug profiling
Epileptiform Discharges (ED) correspond to a massive and synchronous discharge of a group of neurons over a large brain area, in the absence of any electrical stimulation. Those epileptiform discharges are observed in the EEG of 95% of patients suffering from Epilepsy, whereas they are observed in less than 5% in the EEG of non-epileptic patients.
Comparable ED can be observed in rodent brain hippocampal slices exposed to certain pro-convulsive compounds. Our chemically-induced ED model allow for the recording if your compound’s effect in rodent hippocampal brain slices.
>> Download our sample assay evaluating Lamotrigine on 4-AP induced Epileptiform Discharges: Evaluation of a concentration range of Lamotrigine on 4-AP induced EDs in enthorinal cortex slices
- Organotypic slice model of temporal lobe epilepsy (contact us for more details)
in vivo models
- Our partner KEY-OBS, preclinical CNS CRO specialized in in vivo models of neurological disorders and behavioral studies, offers two in vivo models of epilepsy:
- PTZ-induced models (chemically induced seizures model)
- Audiogenic-induced seizure model (accoustic-induced model)
Are you currently working on compounds targeting Epilepsy?
Contact us for any additional information regarding our Epilepsy models.
