A chronic disorder
Epilepsy is one of the most common neurological conditions, and affects up to 50 millions people throughout the world. Epilepsy describes recurrent and unprovoked (not related to another immediate specific health condition) seizures suffered by an individual. Epilepsy is most commonly diagnosed in children and adolescents, or later on in life when cardiovascular diseases and stroke risk increases.
Even though family factor and brain injury can be the source of unprovoked seizures, in most cases the original cause is unknown.
in vitro and in vivo models of Epilepsy
in vitro models
- Our member NEUROSERVICE, our member expert in cell and slice electrophysiology, proposes a wide range of in vitro assays to help your AED research programs.
Epileptiform Discharges (ED) correspond to a massive and synchronous discharge of a group of neurons over a large brain area, in the absence of any electrical stimulation. Those epileptiform discharges are observed in the EEG of 95% of patients suffering from Epilepsy, whereas they are observed in less than 5% in the EEG of non-epileptic patients.
Comparable ED can be observed in hippocampal slices exposed to certain pro-convulsive compounds. ED can be reduced by anti-epileptic drugs (AED) in vivo as well as in vitro. .
in vivo models
- Our member KEY-OBS, preclinical CNS CRO specialized in in vivo models of neurological disorders and behavioral studies, offers two in vivo models of epilepsy:
- PTZ-induced models (chemically induced seizures model)
- Audiogenic-induced seizure model (accoustic-induced model)
Are you currently working on compounds targeting Epilepsy?
Please contact us for any additional information and we will gladly come back to you. We can also set up a dedicated meeting between you and our experts to discuss our CRO services and your research needs.