At Neuroservices-Alliance, we are excited to present our latest research findings on human iPSC-derived NGN2 neurons electrophysiology in collaboration with Biogen. Our poster, showcased at the SfN 2024, delves into the functional characterization of NGN2-derived neurons using both patch clamp and high-density microelectrode array (HD-MEA) techniques.
Human iPSC-derived neurons, such as NGN2 neurons, offer a promising in vitro model to predict therapeutic efficacy for neuroscience research. While most studies focus on their mRNA expression, our research goes a step further by highlighting their electrophysiological properties. This approach allows for a more comprehensive understanding of neuronal function and drug responsiveness.
Our work not only demonstrates the physiological relevance of NGN2 neurons but also underscores their potential for supporting lead optimization in drug development, especially for CNS therapies.
Electrophysiological profiling the functional properties of human NGN2 neurons – Neuroscience 2024
*R. E. PETROSKI1, C. M. PETROSKI1, D. LIU1, S. GRIGORYEV1, M. HE1, K. LEE2, C. A. HINCKLEY2
1Neuroservices-Alliance, San Diego CA 92121, 2Biogen