Based in San Diego, California, Neuroservice USA benefits from the 14 years of experience of Neuroservice in providing pharmacological assays based on electrophysiological recordings, and focuses on human cells recordings (human iPSC-derived neurons and human DRG sensory neurons) as well as non human in vitro ephy recordings.
Thanks to efficient and collaborative scientific interactions and robust functional data, Neuroservice USA work supports decision making in any phases of CNS/PAIN drug discovery research programs.
Thanks to a complete master of Patch-clamp & Calcium Imaging techniques, Neuroservice USA investigates your compound’s effects on neuronal networks and single neurons, specifically iPSC neurons derived from human donors (healthy or patients).
Depending on the pathology targeted by your compound, Neuroservice USA researchers will propose protocols tailored to your needs and reveal your compound properties: pharmacological properties, target(s), Mechanism(s) of Action and Safety issues.
In addition, Neuroservice USA proposes electrophysiological characterization services of iPSC-derived neurons (proprietary or commercial cell lines).
Neuroservice USA performs recordings from various rodent and human tissue:
Neuroservice is a world-renowned leader in patch clamp electrophysiology. Patch Clamp allows in vitro evaluation of compounds under the most physiologically relevant conditions.
Calcium Imaging can either measure individual cell or global neuronal network Ca+ dynamics at a very high resolution. Calcium Imaging analysis tools allow to circle regions of interest in the studied neuronal culture, so that AP firing can be measured locally.