As a chronic neurodegenerative disease affecting the CNS, Parkinson’s Disease present progressive symptoms such as slow movements, tremor, muscle stiffness and cognitive impairment.
Parkinson’s Disease is a synucleopathic disease. It is a consequence of the loss of dopaminergic neurons associated with the anatomopathological landmark, the presence of Lewy Bodies, that are intracellular aggregation of proteins. Among these proteins can be found the Synuclein, the Ubiquitin and many others. Besides the loss of dopaminergic neurons in Parkinson’s Disease, there is the loss of a number of brain areas.
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