On- demand Access to Scientific
Posters & Data

• Characterization of human iPSC-derived neurons

Patch Clamp

• Patch Clamp and Calcium imaging – Functional endpoints for drug discovery

Calcium Imaging 

• Cell Ephy – Calcium Imaging in Neuron Cultures

HD MEA

• MaxWell HD MEA – Recordings of iPSC derived neurons
• NS USA – HD MEA Recordings of iPSC Derived Neurons
• MaxWell HD-MEA Assay Development and Pharmacological Validation

Poster Presentations

2024 – SfN – Neuroscience

• Electrophysiological profiling the functional properties of human NGN2  neurons

2024 – MaxWell Biosystems Neuronal Summit

• HD-MEA recording of primary rat neuron cultures and human iPSC-derived neuron cultures growing at low density on astrocyte feeder layers (new data)

2024 – SLAS 

• Patch clamp and MEA profiling the function of human iPSC-derived nociceptors – SLAS 2024

2023 – SfN – Neuroscience

• Development and validation of a high-density MEA pharmacology assay in rat cortical neurons and human iPSC-derived neurons for drug discovery

• Patch Clamp Profiling the Functional Properties of Human iPSC-Derived Nociceptors
• Characterizing the Maturation of Electrophysiological Properties in Stem Cell-Derived Human Neurons Lacking Methyl CpG Binding Protein 2 (MECP2)

2023 – MaxWell Biosystems Neuronal Summit

• High density MEA recording of primary rat neuron cultures and human iPSCs

2022 – SfN – Neuroscience

• Pharmacology of TTX-resistant & sensitive Na currents in NHP DRG sensory neurons

2022 – IASP – International Association for the Study of Pain

• Profiling the Functional Phenotype of Dorsal Root Ganglia (DRG) Sensory Neurons from the K/BxN Murine Rheumatoid Arthritis Model

2021 – ISSCR – International Society for the Stem Cell Research 

• Functional Endpoints from Human iPSC-derived sensory neurons for pain drug discovery

MEA Data by brain region

• Brain Nuclei
• CA1 Neurons Firing
• Cerebellum
• Cortex
• Network Oscillations
• NMDA-Mediated EPSP
• Spinal Cord Dorsal Horn
• Synaptic-Transmission and Plasticity in Hippocampus

MEA Data Sheets

• Access MEA Data Sheets

Patch Clamp Data Sheets

• Access Patch Clamp Data Sheets

HD MEA

• HD MEA and AI for powerful data analysis

Poster Presentations

2022 Sfn Neuroscience 

• Selective SSTR4 Agonists Mediate Membrane Hyperpolarization and Reduced Intrinsic Firing in CA1 Pyramidal Neurons from Humanized SSTR4 Rats and Human

2019 SfN Neuroscience 

• Assessment of spine density and brain morphological phenotype in three rodent models of neurodevelopmental psychiatric disorders

2017 Sfn Neuroscience

• MEA recordings in rat spinal cord slices for applied pharmacological investigations

2014 SfN Neuroscience 

• In Vitro Recordings of Gamma Oscillations with MEA for the characterization of CNS drugs

• Characterization of Htt-Q130-LEH, a novel heterozygous knock-in rat model of Hungtington’s Disease

Publications

2013 -PLOS Biology

• – HDAC4 Reduction: A novel therapeutic strategy to target Cytoplasmic Hungtingtin and ameliorate neurodegeneration

2018 -Pharmazie

• – Effects or mirogabalin, a novel ligand for the α 2δ  subunit of voltage-gated calcium channels, on N-type calcium channel currents of rat dorasl root ganglion culture neurons

2016 – Elsevier

• – The novel KMMO inhibitor CHDI–340246 leads to a restoration of electrophysiologycal alterations in mouse models of Hungtington’s Disease

2016 – Neuron

• – Phospodiesterase 10A inhibition improves cortico-basal ganglia function in Hungtington’s Disease models

In vivo Brain Ephy – Recording Solutions Overview

Detailed Capacities

• Methodoloy – Analyses – Study Cases
• In Vivo Brain Ephy – Detailed Capacities

Fear and Anxiety

• In Vivo Brain Ephy – Fear & Anxiety – Recordings Analysis of Neuronal Signals

• In Vivo Spinal Cord & DRG Ephy – Recording of Nociceptors in the Anesthetized Mice
• In Vivo Spinal Cord & DRG Ephy – In Vivo Recordings of DRG neurons

2023 – SfN – Neuroscience

• Establishment of a preclinical migraine model based on nitroglycerine-induced sensitization of spinal trigeminal parabrachial neurons in the anaesthetized rat

2019 – SfN – Neuroscience

• Differential sensitization of lamina I and lamina III-V neurons projecting to and/or through the parabrachial area in chronic inflammatory condition in anaesthetized mice