Synaxys brings deep expertise in electrophysiological characterization of complex human neural systems, operating from France with a foundation in advanced neuro-engineering and drug discovery support. Founded in 2018, Synaxys has pioneered human-derived 3D neural platforms such as the proprietary 5D-Brain model, offering high-fidelity functional readouts across spatial, temporal and activity dimensions to accelerate translational research. With many years of experience in CNS pharmacology and neural network analysis, Synaxys collaborates with academic institutions, biotech partners and pharmaceutical companies to deliver mechanistic insight and robust preclinical data that inform key development decisions.
Our organoid platform leverages these cutting-edge human-relevant models to capture complex network activity and functional phenotypes that conventional 2D systems cannot provide, delivering translational endpoints that closely reflect in vivo physiology. By incorporating organoid electrophysiology and network dynamics into preclinical workflows, clients gain earlier insight into compound efficacy, safety, mechanism of action and target engagement, helping de-risk CNS discovery programs and streamline lead optimization with predictive functional data.
Supporting clients working in therapeutic areas such as
Drug Positioning
Therapeutic evaluation in disease model
Neuro-oncology
Example drug targets we cover
Compound tested:
Recordings are performed in healthy and diseased 3D in vitro neuronal cell cultures from a wide variety of primary cell types
Recordings are performed in healthy and diseased 3D in vitro neuronal cell cultures from a wide variety of primary cell types
Recordings are performed in healthy and diseased 3D in vitro neuronal cell cultures from a wide variety of primary cell types
Download our one-pager showcasing our organoid electrophysiology capabilities for predictive CNS drug development
Learn moreDownload our presentation summarizing our 5D Brain Alzheimer disease model and its multi-endpoint functional, molecular, and electrophysiological readouts
Learn moreRead our publication summarizing our capability to visualize spatial and temporal mapping of electrophysiological data across a 3D volume of an in vitro neural network
Learn more