NEUROSERVICE is the world-leading CRO for in vitro electrophysiological assays dedicated to CNS and PNS pharmacology.
NEUROSERVICE has a unique expertise for the recording of brain and spinal cord acute slices with Multi-Electrode Arrays and Patch-Clamp.
NEUROSERVICE provides an exceptional expertise for the design, the performance and the analysis of complex electrophysiological/pharmacological protocols. With a large band-width and short turnarounds, NEUROSERVICE accelerates your CNS Drug Discovery programs until the IND claim.
Thanks to a complete master of Multi-Electrode Arrays and Patch-clamp techniques, NEUROSERVICE is able to investigate your compound effects on neuronal networks and single neurons. Depending on the pathology targeted by your compound, NEUROSERVICE researchers will propose protocols related to the “regions of interest”. We can isolate any brain region and perform the most adapted protocol to reveal your compound properties: pharmacological properties, target(s), Mechanism(s) of Action, and safety issues.
We can record spontaneous firing activities, evoked-responses (electrical or chemical stimulations), synaptic transmission, short-term and long-term synaptic plasticity. In addition we can investigate more subtle parameters such as miniature excitatory or inhibitory currents or perform single-channels recordings.
NEUROSERVICE elegant protocols allow documenting the profile of agonists, partial agonists, inverse agonists, competitive and non-competitive antagonists, positive or negative allosteric modulators.
NEUROSERVICE has a long experience for the characterization of genetically-modified rodents (mice or rats) for many neurodegenerative and neuro-muscular diseases. Compounds can be evaluated in brain slices or spinal cord slices prepared from commercially available transgenic mice or rats (acute exposure or chronic exposure). Recordings can be performed in slices prepared from rats (up to 18 months) or mice (up to 24 months).
NEUROSERVICE has dedicated assays for pain-killer compounds: cultured rodent sensory neurons (from DRG), spinal cord recordings and discrimination between layers 1-2 and layers 4-5 in the dorsal horn. Based on the MEA technique, NEUROSERVICE proposes a quick screening assay on capsaicin-evoked firing activity (morphine and lidocaine as reference compounds).