Exploring Functional Properties of iPSC-Derived Neurons with MaxTwo HD-MEA

Exploring Functional Properties of iPSC-Derived Neurons with MaxTwo HD-MEA


Discover the cutting-edge capabilities of the MaxTwo HD Multi-Electrode Array from Maxwell Biosystems in our latest video.

At Neuroservices-Alliance, we measure the functional properties of iPSC-derived neurons with precision and efficiency.

Our partnership with Maxwell Biosystems allows us to utilize this advanced technology, offering high-throughput and non-destructive electrophysiology recordings.

Learn how our team leverages this tool to enhance our recording capabilities and drive groundbreaking research in neuroscience: watch the video now to explore the innovative features of the MaxTwo HD MEA and its applications in neuroscience research.

Bob Petroski, PhD, CSO of Cell Electrophysiology, Neuroservices-Alliance
At Neuroservices Alliance, we measure the functional properties of iPSC-derived neurons. When I say functional properties, I’m talking about the electrical excitability of those neurons. We record them in current-clamp mode, meaning the action potential firing of those cells. But we can also record in voltage-clamp mode to measure specific ionic currents such as voltage-gated ion channels, ligand-gated ions channels or GPCR modulation of ion channels.

Laura D’Ignazio, PhD, Senior Key Account Manager – MaxWell Biosystems
Our MaxTwo is our next generation electrophysiology platform the MaxTwo allow you to record high quality electrophysiological data by using 6- or 24- wells plates. The key feature here is that in each of the wells there are going to be 26,400 electrodes that you can eventually use to record the functional activity of your samples, in this case iPSC-derived neurons for example.

Bob Petroski, PhD
The great advantage of the MEA is one, much greater throughput, so we can record from thousands to hundreds of thousands of neurons at a time compared to one neuron at a time by patch clamping. And two, it is non destructive. So we can record from the same dish of neurons over many, many weeks, typically up for four to six weeks in culture.

Laura D’Ignazio, PhD
We offer different type of essay. For example the activity scan essay, then you can use the network assay, but You can also go a step further and really look at the cellular level or sub-cellular level and you can even trace the activity at the axonal level.

Bob Petroski, PhD
The customer support of MaxWell is outstanding. The learning curve was very short because the user interface in the software is very easy to use and they provide excellent training. So, not only is the technology outstanding, very low noise recording so you can resolve single-unit activity, but the ability to use the instrument to acquire and analyze your data is spectacular.
That pharmacology data that I am generating with the MaxTwo HD-MEA is matching perfectly with our whole-cell patch clamp data.

Laura D’Ignazio, PhD
Because really our platform is made to help our user to get information not only for example, if they’re interested in drug screening, in the drug discovery in general, pharmacology, but also if they want in general to characterize the activity of their sample. So in case they’re working with disease modeling or phenotyping and all of those types of application.

Thank you for your interest.

Deep-Dive in our published assay

Are you willing to learn more about our expertise in HD-MEA recordings of iPSC-derived neurons? Click on image to download our poster presented with MaxWell Biosystems at SfN 2023:

Development and validation of high-density MEA pharmacology assay in rat cortical neurons and human iPSC-derived neurons for drug discovery.

Preview of a poster showcasing HD MEA recordings on cells

Are you interested in getting a live introduction of our expertise and assessing how our capabilities suit your ongoing needs?

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