Located in San Diego, California, AnaBios aims to establish the safety and efficacy of novel compounds through its advanced, human-focused translational technologies.
AnaBios’ human tissue-based methods provide a very powerful strategy that combines the benefit of in vivo measurements (in animals) with the ability to generate human data (ex vivo) to overcome the challenges of cross-species translation.
AnaBios’s objective is to generate human ex vivo data for the biopharmaceutical industry:
AnaBios offers early human insights into the drug development process and is redefining “First-in-Human” studies. Leveraging extensive knowledge of human tissue procurement and strategic utilization, AnaBios provides the unprecedented opportunity to de-risk drug development programs by assessing the safety and efficacy of drugs directly in human tissues and cells at the preclinical stage.
Human dorsal root ganglia (hDRG) cultured neurons from Normal and Chronic Pain Donors
Techniques (Assays in isolated adult hDRG neurons):
– Electrophysiology – current clamp
– Calcium imaging with electrical field stimulation
Identification of Nav blockers that inhibit action potentials in neurons sensitized with inflammatory agents (reference compound data).
Learn moreCarbamazepine and CNV 1427400 Exhibit Similar Pharmacology in Rat and Human Native DRGs. Download the poster to learn more.
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