Our team aims at elucidating the spatio-temporal evolution of memory traces and of their underlying cerebral support during memory processing in healthy and pathological conditions such as Alzheimer’s disease. We have made important breakthroughs, such as the identification of early tagging of cortical networks as a prerequisite for the formation of enduring associative memory.
We also unraveled some of the molecular mechanisms involved in the formation of remote memories, including the interaction of the CaMKII protein with NMDA receptors known to play a key role in neuronal plasticity. Currently, our research focuses on the functional contribution of NMDA receptors subtypes and of their molecular partners, as well as that of vascular networks, to the stabilization of remote memories during the course of systems-level memory consolidation.
Optopath Expert in Memory Deficits