In addition to paralysis and sensory deficit, orthostatic hypotension is often a consequence of spinal cord injury (SCI).
In normal conditions, the baroreflex activates the sympathetic branch of the autonomic nervous system if a reduction of blood pressure is perceived and restores blood pressure by increasing vascular resistance. By interrupting the connection between the lower brain stem and sympathetic neurons, SCI impairs the baroreflex.
A recent publication in Nature explains how baroreflex can be restored thanks to a neuroprosthetic device, TESS (Targeted Epidural Spinal Stimulation), that triggers sympathetic responses altering blood pressure.
As a world class expert in innovative technologies for neurodegenerative diseases research, our member MOTAC Neuroscience Ltd conducted experiments on NHPs leading to this major breakthrough in its Beijing facility.
Read the article on Nature’s website (full publication accessible to subscribers only).